Barluenga Lecture

 
Prof. Dr. Erick M. Carreira  
Barluenga Lecture

 

  Speaker





 

 

Prof. Dr. Erick M. Carreira

Deputy Head of Laboratory of Organic Chemistry

ETH Zurich
Lab. für Organische Chemie

HCI H 335
Vladimir-Prelog-Weg 1-5/10
8093 Zürich

Switzerland
+41 44 632 28 30
+41 44 632 13 28

2019 Sixth Barluenga Conference

 

Education | Carreira Research Group | Research interest | Selected papers | Funded | Awards
     

Education

 

Education

CV

Erick M. Carreira has been full Professor at the Organic Chemistry Laboratory of the ETH Zurich since August 1998.

Professor Carreira was born in Havana, Cuba in 1963. He obtained a B.S. degree in 1984 from the University of Illinois at Urbana-Champaign under the supervision of Scott E. Denmark and a Ph.D. degree in 1990 from Harvard University under the supervision of David A. Evans. After carrying out postdoctoral work with Peter Dervan at the California Institute of Technology through late 1992, he joined the faculty at the same institution as an assistant professor of chemistry and subsequently was promoted to the rank of associate professor of chemistry in the Spring of 1996, and full Professor in Spring 1997. He is the recipient of the American Chemical Society Award in Pure Chemistry, Nobel Laureate Signature Award, Fresenius Award, a David and Lucile Packard Foundation Fellowship in Science, Alfred P. Sloan Fellowship, Camille and Henry Dreyfus Teacher Scholar Award, Merck Young Investigator Award, Eli Lilly Young Investigator Award, Pfizer Research Award, National Science Foundation CAREER Award, Arnold and Mabel Beckman Young Investigator Award, and a Camille and Henry Dreyfus New Faculty Award. He is also the recipient of the Associated Students of the California Institute of Technology Annual Award in Teaching and a Richard M. Badger Award in Teaching.

His research program focuses on the asymmetric synthesis of biologically active, stereochemically complex, natural products. Target molecules are selected which pose unique challenges in asymmetric bond construction. A complex multistep synthesis endeavor provides a goal-oriented setting within which to engage in reaction innovation and design. Drawing from the areas of organometallic chemistry, coordination chemistry, and molecular recognition, Carreira's group is developing catalytic and stoichiometric reagents for asymmetric stereocontrol, including chiral Lewis acids and transition-metal based reductants.

     

Carreira Research Group



 

Professor Carreira's research program focuses on the asymmetric synthesis of biologically active, stereochemically complex, natural products. Target molecules are selected which pose unique challenges in asymmetric bond construction. A complex multistep synthesis endeavor provides a goal-oriented setting within which to engage in reaction innovation and design. Drawing from the areas of organometallic chemistry, coordination chemistry, and molecular recognition, Carreira's group is developing catalytic and stoichiometric reagents for asymmetric stereocontrol.

Current members

 

   

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Research Interest

 

 

Professor Carreira's research program focuses on the asymmetric synthesis of biologically active, stereochemically complex, natural products. Target molecules are selected which pose unique challenges in asymmetric bond construction. A complex multistep synthesis endeavor provides a goal-oriented setting within which to engage in reaction innovation and design. Drawing from the areas of organometallic chemistry, coordination chemistry, and molecular recognition, Carreira's group is developing catalytic and stoichiometric reagents for asymmetric stereocontrol.

For more information, click on the links below or visit the publications section of the website.

Natural Product Synthesis
Catalytic Methods
Medicinal Chemistry
Chemical Biology

 

Selected Papers

 
 

Recent publications from the Carreira lab:

S.L. Rössler, D.A. Petrone, E.M. Carreira, Acc. Chem. Res. 2019, asap. Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands.

P. Sondermann, E.M. Carreira, J. Am. Chem. Soc., 2019, asap. Stereochemical Revision, Total Synthesis, and Solution State Conformation of the Complex Chlorosulfolipid Mytilipin B.

Y. Sempere, J.L. Alfke, S.L. Rössler, E.M. Carreira, Angew. Chem. Int. Ed., 2019, early view. Morpholine Ketene Aminal as Amide Enolate Surrogate in Iridium‐Catalyzed Asymmetric Allylic Alkylation.

B.S. Schreib, E.M. Carreira, J. Am. Chem. Soc.2019ASAPPalladium-Catalyzed Regioselective C−H Iodination of Unactivated Alkenes.

M. Isomura, D.A. Petrone, E.M. Carreira, J. Am. Chem. Soc.2019141, 4738–4748. Coordination-Induced Stereocontrol over Carbocations: Asymmetric Reductive Deoxygenation of Racemic Tertiary Alcohols.

M. Brandstätter, M. Freis, N. Huwyler, E.M. Carreira, Angew. Chem. Int. Ed., 201958, 2490–2494Total Synthesis of (–)‐Merochlorin A.

S.L. Rössler, B.J. Jelier, P.F. Tripet, A. Shemet, G. Jeschke, A. Togni, E.M. Carreira, Angew. Chem. Int. Ed. 2019131, 536 –541. Pyridyl Radical Cation for C–H Amination of Arenes.

J. Boshkow, T. Scattolin, F. Schoenebeck, E.M. Carreira, Helv. Chim. Acta 2018101, e18001. [1,3]‐Sigmatropic Shift of an Allylic Chloride.

M.J.R. Richter, M. Schneider, M. Brandstätter, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc.2018140, 16704–16710. Total Synthesis of (–)-Mitrephorone A.

A. Chicca, M.A. Schafroth, I. Reynoso-Moreno, R. Erni, V. Petrucci, E.M. Carreira, J. Gertsch, Sci. Adv. 20184, 1–10. Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high.

J.F. Teiber, J. Xiao, G.L. Kramer, S. Ogawa, C. Ebner, H. Wolleb, E.M. Carreira, D.M. Shih, R.W. Haley, Biochem. Biophys. Res. 2018505, 87–92. Identification of biologically active δ-lactone eicosanoids as paraoxonase substrates.

A.G. Kravina, E.M. Carreira, Angew. Chem. Int. Ed. 201857, 13159–13162. Total Synthesis of Epicolactone.

N.Hauser, P. Kraft, E.M. Carreira, Synthesis 201850,4490–4500. Unconventional Rose Odorants: Serendipitous Discovery and Unique Olfactory Properties of 2,2-Bis(prenyl)-3-oxobutyronitrile and Its Derivatives.

Y. Sempere, E.M. Carreira, Angew. Chem. Int. Ed.201857, 7654–7658. Trimethyl Orthoacetate and Ethylene Glycol Mono-Vinyl Ether as Enolate Surrogates in Enantioselective Iridium-Catalyzed Allylation.

H. Wolleb, S. Ogawa, M. Schneider, A. Shemet, J. Muri, M. Kopf, E.M. Carreira, Org. Lett., 201820, 3014−3016Synthesis and Structure–Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues.

N. Sobotzki, M.A. Schafroth, A. Rudnicka, A. Koetemann, F. Marty, S. Goetze, Y. Yamauchi, E.M. Carreira, B. Wollscheid, Nat. Comm. 20189, 1519. HATRIC-based identification of receptors for orphan ligands.

N. Sievertsen, E.M. Carreira, Chimia 201872, 44–47. Apoc Social: A Mobile Interactive and Social Learning Platform for Collaborative Solving of Advanced Problems in Organic Chemistry.

D.A. Petrone, M. Isomura, I. Franzoni, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2018, 140, 4697–4704. Allenylic Carbonates in Enantioselective Iridium-Catalyzed Alkylations.
E.M. Carreira, J. Isr. Chem. 201859, 114–121. Natural Products Synthesis: A Personal Retrospective and Outlook.

M. Soethoudt, S.C. Stolze, M.V. Westphal, L. van Stralen, A. Martella, E.J. van Rooden, W. Guba, Z.V. Varga, H. Deng, S.I. van Kasteren, U. Grether, A.P. IJzerman, P. Pacher, E.M. Carreira, H.S. Overkleeft, A. Ioan-Facsinay, L.H. Heitman, M. van der Stelt, J. Am. Chem. Soc. 2018140, 6067–6075. Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.

L.J. Nannini, Suren J.Nemat, E.M. Carreira, Angew. Chem. Int. Ed.2018130, 831–834. Total Synthesis of (+)-Sarcophytin.

M.V. Westphal, M.A. Schafroth, R.C. Sarott, M.A. Imhof, C.P. Bold, P. Leippe, A. Dhopeshwarkar, J.M. Grandner, V. Katritch, K. Mackie, D. Trauner, E.M. Carreira, J.A. Frank, J. Am. Chem. Soc. 2017139, 18206–18212. Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

   

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Funded work  

Here there is a list of work funded by the European Research Council

 

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Awards  

He is the recipient of the American Chemical Society Award in Pure Chemistry, Nobel Laureate Signature Award, Fresenius Award, a David and Lucile Packard Foundation Fellowship in Science, Alfred P. Sloan Fellowship, Camille and Henry Dreyfus Teacher Scholar Award, Merck Young Investigator Award, Eli Lilly Young Investigator Award, Pfizer Research Award, National Science Foundation CAREER Award, Arnold and Mabel Beckman Young Investigator Award, and a Camille and Henry Dreyfus New Faculty Award. He is also the recipient of the Associated Students of the California Institute of Technology Annual Award in Teaching and a Richard M. Badger Award in Teaching

 

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